A new titanocenyl amide containing flavone as pendant group has been synthesized by reaction of titanocenyl carboxylic acid chloride and 7-Aminoflavone and structurally characterized by spectroscopic methods. This species and eight previously synthesized titanocenyl amide complexes have been tested in breast adenocarcinoma cancer cell line, MCF-7. The functionalization of titanocene dichloride with amides enhances the cytotoxic activity in MCF-7. Two sets of titanocenyl amides can be identified, with I C 5 0 < 1 0 0 ? ?? M and I C 5 0 > 1 0 0 ? ?? M. The most cytotoxic species is Cp(CpCO-NH- C 6 H 4 - ( C H 2 ) 2 C H 3 ) T i C l 2 with an I C 5 0 of 24(2)? ?? M, followed by Cp(CpCO-NH- C 6 H 4 -Br) T i C l 2 , I C 5 0 of 46(4)? ?? M and Cp(CpCO-NH- C 6 H 4 - O C F 3 ) T i C l 2 , I C 5 0 of 49(6)? ?? M. There is no correlation between the nature of the para substituent on the phenyl ring and the cytotoxic properties on MCF-7 cell line.
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